Such reactions can be life threatening or fatal. One will often wake you up an hour or two after you go to bed. Nighttime attacks can be more severe than the daytime ones. Vagus nerve, since the headaches are immediately connected to the urge to have a bowel movement. IMITREX Injection and any ergotamine-containing or ergot-type medication like dihydroergotamine or methysergide should not be used within 24 hours of each other, nor should IMITREX Injection and another 5-HT 1 agonist. zetia stock
Heart Rate: Transient increases in blood pressure observed in some patients in clinical studies carried out during sumatriptan's development as a treatment for migraine were not accompanied by any clinically significant changes in heart rate. You can buy some over the counter. But stronger NSAIDs need a prescription. The onset of symptoms generally occurs within minutes to hours of receiving a new or a greater dose of a serotoninergic medications. Do you have any symptoms before the headache starts? IMITREX can cause dizziness, weakness, or drowsiness.
If you also take any ergotamine medication such as dihydroergotamine or other "triptan" drugs such as zolmitriptan, rizatriptan you will need to separate your sumatriptan dose from your dose of these other medications to lessen the chance of serious side effects. Ask your doctor how long you should wait between your doses of these drugs. MAO-A inhibitors reduce sumatriptan clearance, significantly increasing systemic exposure. Therefore, the use of sumatriptan in patients receiving MAO-A inhibitors is not ordinarily recommended. What should I avoid while taking IMITREX? Your doctor may ask you to take the first dose in the office.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. This medication may interfere with certain laboratory tests including bleeding times, adrenal function tests possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug. Imitrex Injection is a prescription medicine used to treat acute migraine headaches with or without aura and acute cluster headaches in adults who have been diagnosed with migraine or cluster headaches.
Loi V, Lai M, Pisano MR, Delzompo M "Sumatriptan and panic-like symptoms. Ways to manage your time. Before you use any treatment for a memory problem, discuss the potential risks and benefits of the treatment with your doctor. Take the Pen out of the Carrying Case. Incidence in Controlled Clinical Trials of Migraine Headache: Table 4 lists adverse events that occurred in 2 large US, Phase III, placebo-controlled clinical trials in migraine patients following either a single dose of IMITREX Injection or placebo. Ergot-containing drugs have been reported to cause prolonged vasospastic reactions. Neurological: Infrequent were mental confusion, euphoria, agitation, relaxation, chills, sensation of lightness, tremor, shivering, disturbances of taste, prickling sensations, paresthesia, stinging sensations, facial pain, photophobia, and lacrimation. For subcutaneous injection only. The safety of treating an average of more than 4 headaches in a 30 day period has not been established. Loss of vision included reports of permanent defects. Causality has not been established as visual disorders may occur during a migraine attack itself. There was no evidence of an increase in tumors in either species related to sumatriptan administration. Overdose in animals has been fatal and has been heralded by convulsions, tremor, paralysis, inactivity, ptosis, erythema of the extremities, abnormal respiration, cyanosis, ataxia, mydriasis, salivation, and lacrimation. This medicine may cause stomach bleeding. Cardiovascular: Infrequent were hypertension, hypotension, bradycardia, tachycardia, palpitations, pulsating sensations, various transient ECG changes nonspecific ST or T wave changes, prolongation of PR or QTc intervals, sinus arrhythmia, nonsustained ventricular premature beats, isolated junctional ectopic beats, atrial ectopic beats, delayed activation of the right ventricle and syncope. Rare were pallor, arrhythmia, abnormal pulse, vasodilatation, and Raynaud syndrome. Pregnancy Registry: To monitor fetal outcomes of pregnant women exposed to IMITREX, GlaxoSmithKline maintains a Sumatriptan Pregnancy Registry. Physicians are encouraged to register patients by calling 800 336-2176. If your doctor decides to stop your treatment, do not keep any leftover medicine unless your doctor tells you to. Throw away your medicine as instructed.
The risk of heart disease, liver disease, and high blood pressure increases with age. The manufacturer does not recommend the use of sumatriptan in the elderly since they may be more sensitive to the side effects, including an increase in blood pressure. It may spread to your forehead, temple, nose, cheek, or upper gum on that side. Your scalp may be tender. You can often feel your pulsing. Open the Carrying Case lid. Cavazos JE, Caress JB, Chilukuri VR, Devlin T, Gray L, Hurwitz BJ "Sumatriptan-induced stroke in sagittal sinus thrombosis. Clinical data to determine the frequency of serious adverse reactions in pediatric patients who might receive subcutaneous, oral, or intranasal Imitrex are not presently available. Figure A while you are loading the Pen. IMITREX Injection is a clear, colorless to pale yellow, sterile, nonpyrogenic solution for subcutaneous injection. The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables. vasodilan
Do not touch the needle. For adults, the usual dose is a single injection given just below the skin. It should be given as soon as the symptoms of your migraine appear, but it may be given at any time during an attack. A second injection may be given if your symptoms of migraine come back. If your symptoms do not improve following the first injection, do not give a second injection for the same attack without first consulting with your doctor. Do not have more than 2 injections in any 24 hours and allow at least 1 hour between each dose. Willett F, Curzen N, Adams J, Armitage M "Coronary vasospasm induced by subcutaneous sumatriptan. If you have a higher risk for heart problems see Precautions your doctor may perform a heart exam before you start taking sumatriptan. Welch KM "Drug therapy of migraine. You may experience pain or redness at the site of injection, but this usually lasts less than an hour. The effect of mild to moderate hepatic disease on the pharmacokinetics of subcutaneously administered sumatriptan has been evaluated. There were no significant differences in the pharmacokinetics of subcutaneously administered sumatriptan in moderately hepatically impaired subjects compared with healthy controls. The pharmacokinetics of subcutaneously administered sumatriptan in patients with severe hepatic impairment has not been studied. If your migraine symptoms go away and then come back, you may use a second dose as directed by your doctor. Wait at least 2 hours between doses. Choose and Prepare the Injection Site. If you use too much IMITREX, call your healthcare provider or go to the nearest hospital emergency room right away. hydroxyzine review hydroxyzine
Attacks appear to be linked to the circadian rhythm, your body's 24-hour clock. They happen so regularly, generally at the same time each day, that they've been called "alarm clock headaches. Sumatriptan belongs to a group of drugs called triptans. It affects a certain natural chemical serotonin that constricts blood vessels in the brain. It may also block other pain pathways in the brain. Treatment for these health problems also may help you have fewer headaches. Imitrex spray. Be sure you understand how to use Imitrex spray. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions. If you do not get any relief after your first tablet, do not take a second tablet without first talking with your healthcare provider. Postmarketing Experience With Sumatriptan: Serious cardiovascular events, some resulting in death, have been reported in association with the use of IMITREX Injection or IMITREX Tablets. The uncontrolled nature of postmarketing surveillance, however, makes it impossible to determine definitively the proportion of the reported cases that were actually caused by sumatriptan or to reliably assess causation in individual cases. On clinical grounds, the longer the latency between the administration of IMITREX and the onset of the clinical event, the less likely the association is to be causative. Accordingly, interest has focused on events beginning within 1 hour of the administration of IMITREX. Inform patients that the injection is intended to be given subcutaneously and intramuscular or intravascular delivery should be avoided. Instruct patients to use injection sites with an adequate skin and subcutaneous thickness to accommodate the length of the needle. IMITREX should also be administered with caution to patients with diseases that may alter the absorption, metabolism, or excretion of drugs, such as impaired hepatic or renal function. Burns and scars have been reported on the skin where the transdermal iontophoretic transdermal system has been worn. These reports describe severe redness, pain, skin discoloration, blistering, and cracked skin. On June 13, 2016, the manufacturer of the patch suspended sales and distribution of the patch to investigate the cause of these reports. They are usually triggered after pain medicine has worn off, prompting you to take another dose. Eventually you get a headache whenever you stop taking the drug. Be sure to take your migraine medicine only as prescribed by your doctor. Sumatriptan belongs to a group of drugs called triptans. cheap ezetimibe rezeptfrei
Do not press the Blue Button yet. Musculoskeletal: Infrequent were various joint disturbances pain, stiffness, swelling, ache. Rare were muscle stiffness, need to flex calf muscles, backache, muscle tiredness, and swelling of the extremities. The incidence of adverse reactions in controlled clinical trials was not affected by gender or age of the patients. There were insufficient data to assess the impact of race on the incidence of adverse reactions. Studies 2 and 3 the onset of relief was less than 10 minutes. Headache relief, as defined by a reduction in pain from severe or moderately severe to mild or no headache, was achieved in 70% of the patients within 1 hour of a single 6-mg subcutaneous dose of Imitrex Injection. Approximately 82% and 65% of patients treated with IMITREX 6 mg had headache relief and were pain free within 2 hours, respectively. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. The risk increases if you are also taking other drugs that increase serotonin, so tell your doctor or pharmacist of all the drugs you take see Drug Interactions section. This Patient Information leaflet summarizes the most important information about IMITREX. If you would like more information, talk with your healthcare provider. You can ask your healthcare provider or pharmacist for information about IMITREX that is written for healthcare professionals. This should not be taken if you have certain medical conditions. IMITREX Injection, call your doctor immediately. Imitrex is a prescription medicine used to treat acute migraine headaches with or without aura in adults. The following wording is contained in a separate leaflet provided for patients. The pharmacokinetics of sumatriptan in the elderly mean age: 72 years, 2 males and 4 females and in subjects with migraine mean age: 38 years, 25 males and 155 females were similar to that in healthy male subjects mean age: 30 years. There are many headache remedies. Medications can ease your pain, but changing your lifestyle to control stress or avoid triggers works well, too, and may prevent you from getting headaches. What works for one person may not work for another, so work with your doctor to find the best remedy for you.
Urogenital: Abnormal menstrual cycle, abortion, bladder inflammation, endometriosis, hematuria, increased urination, inflammation of fallopian tubes, intermenstrual bleeding, menstruation symptoms, micturition disorders, urethritis, and urinary infections. Therefore, do not use this medication more often or for longer than prescribed. Sumatriptan may also be used for purposes not listed in this medication guide. What is the most important information I should know about Imitrex Statdose sumatriptan injection? No gross overdoses in clinical practice have been reported. He gave me a quick once over and assumed it was a migraine. He did have them give me a CAT Scan just to make sure he wasn't missing anything like an aneurysm, but the test ruled that out. He thought I would be extastic to know that, but I at the time I was still hoping for death and I was in the worst pain ever! But doctors have found that inhaling pure oxygen can work very well to bring relief. Pain medicine such as that goes inside the nose helps some people. buy pyridium online south africa
NSAIDs with them. Talk to your doctor before taking any over-the-counter meds if you take other medicines, supplements, or have any medical problems. Drowsiness may occur during a migraine or during its treatment with this drug. Do not drive or operate machinery until you know how this drug affects you. Single doses of 5, 10, or 20 mg of Imitrex Nasal Spray administered into 1 nostril were effective for the acute treatment of migraine in adults. Sumatriptan injection comes in a vial bottle an auto-injector or prefilled cartridge to be loaded into an auto-injector syringe, or in a needle-free injector device. Each vial, cartridge, or needle-free device is for one use only. Do not touch this area again before giving the injection. Product Information. Imitrex nasal spray sumatriptan. Clinical trials of Imitrex Tablets did not include sufficient numbers of patients aged 65 and older to determine whether they respond differently from younger patients. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function and of concomitant disease or other drug therapy. Imitrex tablets are a serotonin 5-HT 1 receptor agonist "triptan". It works by narrowing blood vessels in the brain, which helps to relieve migraines. IMITREX may cause serious side effects. Studies show caffeine makes pain relievers more effective and may help your body absorb other drugs, Calhoun says. But it has some drawbacks. Injection in pregnant women. The Pen is used to automatically inject 1 dose of medicine from a Syringe Cartridge. Follow-up care is a key part of your treatment and safety. Be sure to make and go to all appointments, and call your doctor if you are having problems. It's also a good idea to know your test results and keep a list of the medicines you take. You may begin to sweat a lot, or light may bother you. Read this Patient Information before you start taking IMITREX and each time you get a refill. There may be new information. This information does not take the place of talking with your healthcare provider about your medical condition or treatment. elop.info neotrex
After using sumatriptan nasal spray, you must wait two 2 hours before using a second spray. Do not use more than 40 mg of sumatriptan nasal spray in 24 hours. What happens if I overdose? You may have to try different drugs or doses. If you have already tried several medicines, your doctor may order tests such as an or to find out if a health problem is causing your headaches. IMITREX. Such reactions can be life threatening or fatal. Read this Patient Information before you start taking Imitrex and each time you get a refill. There may be new information. This information does not take the place of talking with your healthcare provider about your medical condition or treatment. IMITREX can cause dizziness, weakness, or drowsiness. If you have these symptoms, do not drive a car, use machinery, or do anything where you need to be alert. Different types of medicine treat different types of headaches. Tension headaches: Pain relievers such as acetaminophen, aspirin, ibuprofen, or naproxen, usually help. But be careful. Taking too many of these pills can cause hard-to-treat rebound headaches. If you need to take these drugs often, see your doctor. Do not give aspirin to anyone under age 19 -- it raises their risk for a serious condition called Reye's syndrome. Check the expiration date on the Cartridge Pack. Do not dispose of your used sharps disposal container in your household trash unless your community guidelines permit this. Do not recycle your used sharps disposal container. IMITREX STATdose Pen, 2 prefilled single-dose syringe cartridges, and 1 carrying case NDC 0173-0739-00. Sumatriptan succinate is a white to off-white powder that is readily soluble in water and in saline. gabapentin
When nothing else has worked, surgery may be an option for people who don't get a break from cluster headaches. Most of the procedures involve blocking the trigeminal nerve. Studies 2 and 3 the onset of relief was less than 10 minutes. Best of luck to you. This is a very scarey and painful problem. The vascular 5-HT 1 receptor subtype to which sumatriptan binds selectively, and through which it presumably exerts its antimigrainous effect, has been shown to be present on cranial arteries in both dog and primate, on the human basilar artery, and in the vasculature of the isolated dura mater of humans. In these tissues, sumatriptan activates this receptor to cause vasoconstriction, an action in humans correlating with the relief of migraine and cluster headache. In the anesthetized dog, sumatriptan selectively reduces the carotid arterial blood flow with little or no effect on arterial blood pressure or total peripheral resistance. In the cat, sumatriptan selectively constricts the carotid arteriovenous anastomoses while having little effect on blood flow or resistance in cerebral or extracerebral tissues. Imitrex is a registered trademark of the GlaxoSmithKline group of companies. Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. 'Multum' is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Feeling hot or cold, weak, or "strange" in some way. Drug-Associated Cardiac Events and Fatalities: Serious adverse cardiac events, including acute myocardial infarction, life-threatening disturbances of cardiac rhythm, and death have been reported within a few hours following the administration of IMITREX Injection or IMITREX sumatriptan succinate Tablets. Considering the extent of use of sumatriptan in patients with migraine, the incidence of these events is extremely low. Have you had, or do you have, any disease of the liver or kidney? Do not share this medication with others. Do not consider WebMD User-generated content as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately. Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.
Always consult a healthcare professional for medical advice. If your symptoms do not improve after the first dose, do not use a second dose for the same attack. Contact your doctor. Store Imitrex spray between 36 and 86 degrees F 2 and 30 degrees C. Store away from heat, moisture, and light. Do not freeze. Do not store at temperatures above 86 degrees F 30 degrees C. Do not store in the bathroom. Keep Imitrex spray in the case provided. Throw away expired medicine as directed by your doctor the expiration date is printed on the treatment pack. Keep Imitrex spray out of the reach of children and away from pets. Curtin T, Brooks AP, Roberts JA "Cardiorespiratory distress after sumatriptan given by injection. IMITREX is not for people with risk factors for heart disease unless a heart exam is done and shows no problem. Triptans work best when they are taken as soon as the headache starts. But they can still reduce headache pain and other symptoms when taken after the attack has begun. Ask your healthcare provider or pharmacist for a list of these medicines if you are not sure. The nerve that's affected, the trigeminal nerve, is responsible for sensations such as heat or pain in your face. Now, I am drinking Pedialyte, in hopes of staving off the headache. An autoinjector device IMITREX STATdose Pen is available for use with 4-mg and 6-mg prefilled syringe cartridges. Pain, swelling, bleeding, or bruising at the injection site may occur. cheap imuran online pills
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GSK group of companies. 10000000124083 Rev. Remember, if you answered YES to any of the above questions, then discuss it with your doctor. What are the ingredients in IMITREX Injection? Imitrex, IMITREX STATdose Pen, and IMITREX STATdose System are registered trademarks of the GSK group of companies. torsemide
Important: The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, blogs, or WebMD Answers are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. Five controlled clinical trials 2 single-attack trials, 3 multiple-attack trials evaluating oral IMITREX 25 to 100 mg in pediatric patients 12 to 17 years of age enrolled a total of 701 pediatric migraineurs. These trials did not establish the efficacy of oral IMITREX compared with placebo in the treatment of migraine in pediatric patients. Adverse reactions observed in these clinical trials were similar in nature to those reported in clinical trials in adults. The frequency of all adverse reactions in these patients appeared to be both dose- and age-dependent, with younger patients reporting reactions more commonly than older pediatric patients.
Rare were and increased urination. IMITREX Injection 1 hour after the initial injection. Endocrine and Metabolic: Infrequent was thirst. Imitrex. Such reactions can be life threatening or fatal. In general, anaphylactic reactions to drugs are more likely to occur in individuals with a history of sensitivity to multiple allergens. Imitrex Tablets are contraindicated in patients with a history of hypersensitivity reaction to Imitrex. Injection is contraindicated in patients with a history of stroke or TIA.
The unit contains only 1 spray. Do NOT test it before use. Some people may have feelings of tingling, heat, flushing redness of face lasting a short time heaviness or pressure after treatment with IMITREX Injection. A few people may feel drowsy, dizzy, tired, or sick. Tell your doctor of these symptoms at your next visit. Skin: Infrequent were erythema, pruritus, and skin rashes and eruptions. Rare was skin tenderness. It is unclear whether the nausea and vomiting is related to sumatriptan therapy or to the underlying condition. Plot. Patients taking rescue medication were censored at 15 minutes.